Salem

Tomacco was originally a fictional plant that was a hybrid between tomatoes and tobacco, from a 1999 episode of The Simpsons titled "E-I-E-I-(Annoyed Grunt)". The method used to create the tomacco in the episode is fictional. In the episode, the tomacco was accidentally created by Homer Simpson when he planted and fertilized his tomato and tobacco fields with plutonium. The result is a tomato that apparently has a dried, brown tobacco center, and, although being described as tasting terrible by many characters, is also immediately and powerfully addictive. The creation is promptly labeled "tomacco" by Homer and sold in large quantities to unsuspecting passersby. A cigarette company, Laramie Tobacco Co., seeing the opportunity to legally sell their products to children, offers to buy the rights to market tomacco, but Homer demands one thousand times as much money as they wish to pay him, and the company withdraws. Eventually, all of the tomacco plants are eaten by farm animals — except for the one remaining plant, which later goes down in an explosive helicopter crash with the cigarette company's lawyers.

The process of making tomacco was first revealed in a 1959 Scientific American article, which stated that nicotine could be found in the tomato plant after grafting. Due to the academic and industrial importance of this breakthrough process, this article was reprinted in a 1968 Scientific American compilation.[16]